Impaired somatosensory discrimination of shape in Parkinson's disease: Association with caudate nucleus dopaminergic function
Identifieur interne : 002A39 ( Main/Corpus ); précédent : 002A38; suivant : 002A40Impaired somatosensory discrimination of shape in Parkinson's disease: Association with caudate nucleus dopaminergic function
Auteurs : Bruno J. Weder ; Klaus L. Leenders ; Peter Vontobel ; Matthias Nienhusmeier ; Alex Keel ; Wolfgang Zaunbauer ; Thomas Vonesch ; Hans-Peter LudinSource :
- Human Brain Mapping [ 1065-9471 ] ; 1999.
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Abstract
Tactile discrimination of macrogeometric objects in a two‐alternative forced‐choice procedure represents a demanding task involving somatosensory pathways and higher cognitive processing. The objects for somatosensory discrimination, i.e., rectangular parallelepipeds differing only in oblongness, were presented in sequential pairs to normal volunteers and 12 parkinsonian patients. The performance of patients was significantly impaired compared to normal volunteers. From a biochemical point of view, the patients were characterized by a severely reduced 6‐[18F]‐fluoro‐L‐dopa (FDOPA) tracer metabolism in the basal ganglia, as measured using positron emission tomography (PET). Furthermore, reduced specific FDOPA metabolism in the putamen was consistent with the impaired motor capacities of the patients. The reduced specific FDOPA‐uptake within the caudate nucleus was associated with additionally diminished somatosensory discrimination. This association, of low perception during task performance and decreased FDOPA‐uptake, provides direct evidence for the role of the caudate nucleus in the cognitive part of the task. We suggest that directed attention and working memory were critically involved as a result of disturbed interactions between the head of the caudate nucleus and the dorsolateral prefrontal cortex. Furthermore, there were indications of an additional involvement of the mesolimbic system, which might be of importance during challenging situations such as forced choice. We conclude that differential effects on parts of the basal ganglia, during evolution of the degenerative process characteristic of Parkinson's disease, have profound consequences on the performance of skills, as shown here for a somatosensory discrimination task. Hum. Brain Mapping 8:1–12, 1999. © 1999 Wiley‐Liss, Inc.
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DOI: 10.1002/(SICI)1097-0193(1999)8:1<1::AID-HBM1>3.0.CO;2-E
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The objects for somatosensory discrimination, i.e., rectangular parallelepipeds differing only in oblongness, were presented in sequential pairs to normal volunteers and 12 parkinsonian patients. The performance of patients was significantly impaired compared to normal volunteers. From a biochemical point of view, the patients were characterized by a severely reduced 6‐[18F]‐fluoro‐L‐dopa (FDOPA) tracer metabolism in the basal ganglia, as measured using positron emission tomography (PET). Furthermore, reduced specific FDOPA metabolism in the putamen was consistent with the impaired motor capacities of the patients. The reduced specific FDOPA‐uptake within the caudate nucleus was associated with additionally diminished somatosensory discrimination. This association, of low perception during task performance and decreased FDOPA‐uptake, provides direct evidence for the role of the caudate nucleus in the cognitive part of the task. We suggest that directed attention and working memory were critically involved as a result of disturbed interactions between the head of the caudate nucleus and the dorsolateral prefrontal cortex. Furthermore, there were indications of an additional involvement of the mesolimbic system, which might be of importance during challenging situations such as forced choice. We conclude that differential effects on parts of the basal ganglia, during evolution of the degenerative process characteristic of Parkinson's disease, have profound consequences on the performance of skills, as shown here for a somatosensory discrimination task. Hum. Brain Mapping 8:1–12, 1999. © 1999 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Bruno J. Weder</name><affiliations><json:string>Department of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland</json:string></affiliations></json:item><json:item><name>Klaus L. 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The objects for somatosensory discrimination, i.e., rectangular parallelepipeds differing only in oblongness, were presented in sequential pairs to normal volunteers and 12 parkinsonian patients. The performance of patients was significantly impaired compared to normal volunteers. From a biochemical point of view, the patients were characterized by a severely reduced 6‐[18F]‐fluoro‐L‐dopa (FDOPA) tracer metabolism in the basal ganglia, as measured using positron emission tomography (PET). Furthermore, reduced specific FDOPA metabolism in the putamen was consistent with the impaired motor capacities of the patients. The reduced specific FDOPA‐uptake within the caudate nucleus was associated with additionally diminished somatosensory discrimination. This association, of low perception during task performance and decreased FDOPA‐uptake, provides direct evidence for the role of the caudate nucleus in the cognitive part of the task. We suggest that directed attention and working memory were critically involved as a result of disturbed interactions between the head of the caudate nucleus and the dorsolateral prefrontal cortex. Furthermore, there were indications of an additional involvement of the mesolimbic system, which might be of importance during challenging situations such as forced choice. We conclude that differential effects on parts of the basal ganglia, during evolution of the degenerative process characteristic of Parkinson's disease, have profound consequences on the performance of skills, as shown here for a somatosensory discrimination task. Hum. 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The objects for somatosensory discrimination, i.e., rectangular parallelepipeds differing only in oblongness, were presented in sequential pairs to normal volunteers and 12 parkinsonian patients. The performance of patients was significantly impaired compared to normal volunteers. From a biochemical point of view, the patients were characterized by a severely reduced 6‐[18F]‐fluoro‐L‐dopa (FDOPA) tracer metabolism in the basal ganglia, as measured using positron emission tomography (PET). Furthermore, reduced specific FDOPA metabolism in the putamen was consistent with the impaired motor capacities of the patients. The reduced specific FDOPA‐uptake within the caudate nucleus was associated with additionally diminished somatosensory discrimination. This association, of low perception during task performance and decreased FDOPA‐uptake, provides direct evidence for the role of the caudate nucleus in the cognitive part of the task. We suggest that directed attention and working memory were critically involved as a result of disturbed interactions between the head of the caudate nucleus and the dorsolateral prefrontal cortex. Furthermore, there were indications of an additional involvement of the mesolimbic system, which might be of importance during challenging situations such as forced choice. We conclude that differential effects on parts of the basal ganglia, during evolution of the degenerative process characteristic of Parkinson's disease, have profound consequences on the performance of skills, as shown here for a somatosensory discrimination task. Hum. 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number="7954"></count></countGroup><titleGroup><title type="main" xml:lang="en">Impaired somatosensory discrimination of shape in Parkinson's disease: Association with caudate nucleus dopaminergic function</title><title type="short" xml:lang="en">FDOPA in PET of Parkinson's Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Bruno J.</givenNames><familyName>Weder</familyName></personName><contactDetails><email>bruno_weder@ms1.kssg.ch</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>Klaus L.</givenNames><familyName>Leenders</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Peter</givenNames><familyName>Vontobel</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Matthias</givenNames><familyName>Nienhusmeier</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Alex</givenNames><familyName>Keel</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Wolfgang</givenNames><familyName>Zaunbauer</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Thomas</givenNames><familyName>Vonesch</familyName></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Hans‐Peter</givenNames><familyName>Ludin</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="CH" type="organization"><unparsedAffiliation>Department of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="CH" type="organization"><unparsedAffiliation>PET Center of Paul Scherrer Institute, Villigen, Switzerland</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="CH" type="organization"><unparsedAffiliation>Department of Neurology, University Hospital, Zürich, Switzerland</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="CH" type="organization"><unparsedAffiliation>Institute of Statistics, University of St. Gallen, St. Gallen, Switzerland</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="CH" type="organization"><unparsedAffiliation>Department of Radiology, Kantonsspital St. Gallen, St. Gallen, Switzerland</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">macrogeometric objects</keyword><keyword xml:id="kwd2">somatosensory discrimination</keyword><keyword xml:id="kwd3">Parkinson's disease</keyword><keyword xml:id="kwd4">6‐[<sup>18</sup>F]‐fluoro‐L‐dopa</keyword><keyword xml:id="kwd5">dorsolateral prefrontal circuit</keyword><keyword xml:id="kwd6">directed attention</keyword><keyword xml:id="kwd7">working memory</keyword></keywordGroup><fundingInfo><fundingAgency>Swiss National Foundation (Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung)</fundingAgency><fundingNumber>32‐37400.93</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Tactile discrimination of macrogeometric objects in a two‐alternative forced‐choice procedure represents a demanding task involving somatosensory pathways and higher cognitive processing. The objects for somatosensory discrimination, i.e., rectangular parallelepipeds differing only in oblongness, were presented in sequential pairs to normal volunteers and 12 parkinsonian patients. The performance of patients was significantly impaired compared to normal volunteers. From a biochemical point of view, the patients were characterized by a severely reduced 6‐[<sup>18</sup>F]‐fluoro‐L‐dopa (FDOPA) tracer metabolism in the basal ganglia, as measured using positron emission tomography (PET). Furthermore, reduced specific FDOPA metabolism in the putamen was consistent with the impaired motor capacities of the patients. The reduced specific FDOPA‐uptake within the caudate nucleus was associated with additionally diminished somatosensory discrimination. This association, of low perception during task performance and decreased FDOPA‐uptake, provides direct evidence for the role of the caudate nucleus in the cognitive part of the task. We suggest that directed attention and working memory were critically involved as a result of disturbed interactions between the head of the caudate nucleus and the dorsolateral prefrontal cortex. Furthermore, there were indications of an additional involvement of the mesolimbic system, which might be of importance during challenging situations such as forced choice. We conclude that differential effects on parts of the basal ganglia, during evolution of the degenerative process characteristic of Parkinson's disease, have profound consequences on the performance of skills, as shown here for a somatosensory discrimination task. Hum. Brain Mapping 8:1–12, 1999. © 1999 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Impaired somatosensory discrimination of shape in Parkinson's disease: Association with caudate nucleus dopaminergic function</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>FDOPA in PET of Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Impaired somatosensory discrimination of shape in Parkinson's disease: Association with caudate nucleus dopaminergic function</title></titleInfo><name type="personal"><namePart type="given">Bruno J.</namePart><namePart type="family">Weder</namePart><affiliation>Department of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland</affiliation><description>Correspondence: Klinik für Neurologie, Kantonsspital St. Gallen, CH‐9007 St. Gallen, Switzerland.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Klaus L.</namePart><namePart type="family">Leenders</namePart><affiliation>PET Center of Paul Scherrer Institute, Villigen, Switzerland</affiliation><affiliation>Department of Neurology, University Hospital, Zürich, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter</namePart><namePart type="family">Vontobel</namePart><affiliation>PET Center of Paul Scherrer Institute, Villigen, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matthias</namePart><namePart type="family">Nienhusmeier</namePart><affiliation>Department of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alex</namePart><namePart type="family">Keel</namePart><affiliation>Institute of Statistics, University of St. Gallen, St. Gallen, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wolfgang</namePart><namePart type="family">Zaunbauer</namePart><affiliation>Department of Radiology, Kantonsspital St. Gallen, St. Gallen, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas</namePart><namePart type="family">Vonesch</namePart><affiliation>Department of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hans‐Peter</namePart><namePart type="family">Ludin</namePart><affiliation>Department of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">1999</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">5</extent><extent unit="tables">1</extent><extent unit="references">56</extent><extent unit="words">7954</extent></physicalDescription><abstract lang="en">Tactile discrimination of macrogeometric objects in a two‐alternative forced‐choice procedure represents a demanding task involving somatosensory pathways and higher cognitive processing. The objects for somatosensory discrimination, i.e., rectangular parallelepipeds differing only in oblongness, were presented in sequential pairs to normal volunteers and 12 parkinsonian patients. The performance of patients was significantly impaired compared to normal volunteers. From a biochemical point of view, the patients were characterized by a severely reduced 6‐[18F]‐fluoro‐L‐dopa (FDOPA) tracer metabolism in the basal ganglia, as measured using positron emission tomography (PET). Furthermore, reduced specific FDOPA metabolism in the putamen was consistent with the impaired motor capacities of the patients. The reduced specific FDOPA‐uptake within the caudate nucleus was associated with additionally diminished somatosensory discrimination. This association, of low perception during task performance and decreased FDOPA‐uptake, provides direct evidence for the role of the caudate nucleus in the cognitive part of the task. We suggest that directed attention and working memory were critically involved as a result of disturbed interactions between the head of the caudate nucleus and the dorsolateral prefrontal cortex. Furthermore, there were indications of an additional involvement of the mesolimbic system, which might be of importance during challenging situations such as forced choice. We conclude that differential effects on parts of the basal ganglia, during evolution of the degenerative process characteristic of Parkinson's disease, have profound consequences on the performance of skills, as shown here for a somatosensory discrimination task. Hum. Brain Mapping 8:1–12, 1999. © 1999 Wiley‐Liss, Inc.</abstract><note type="funding">Swiss National Foundation (Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung) - No. 32‐37400.93; </note><subject lang="en"><genre>Keywords</genre><topic>macrogeometric objects</topic><topic>somatosensory discrimination</topic><topic>Parkinson's disease</topic><topic>6‐[18F]‐fluoro‐L‐dopa</topic><topic>dorsolateral prefrontal circuit</topic><topic>directed attention</topic><topic>working memory</topic></subject><relatedItem type="host"><titleInfo><title>Human Brain Mapping</title></titleInfo><titleInfo type="abbreviated"><title>Hum. Brain Mapp.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">1065-9471</identifier><identifier type="eISSN">1097-0193</identifier><identifier type="DOI">10.1002/(ISSN)1097-0193</identifier><identifier type="PublisherID">HBM</identifier><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>1</start><end>12</end><total>12</total></extent></part></relatedItem><identifier type="istex">8EA1A3B16109569F8303044DEA462291E5B0B006</identifier><identifier type="DOI">10.1002/(SICI)1097-0193(1999)8:1<1::AID-HBM1>3.0.CO;2-E</identifier><identifier type="ArticleID">HBM1</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1999 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Inc.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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